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A novel approach is to study electrophysiological properties of cultured cardiac myocytes by micro-electrode arrays (MEA). Common in vitro methods include organ models (Langendorff heart), conventional electrophysiology on cardiac myocytes, and heterologous expression systems of human ether-a-go-go-related gene (hERG) channels. Regulatory authorities such as the US FDA and the European Medicines Agency require in vitro testing of all drug candidates against the potential risk for QT interval prolongation prior to clinical trials.
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This timer counts down silently until it reaches 0:00, then a police siren sounds to alert you that time is up.Drug-induced QT interval prolongation is now a major concern in safety pharmacology. Database administrators should periodically make backup copies of the missing index information if they want to keep it after server … Missing index information is kept only until the database engine is restarted. Information returned by sys.dm_db_missing_index_details is updated when a query is optimized by the query optimizer, and is not persisted.
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